Animal-to-animal variation could account for any differences in the amount of siRNA detected; however, a clear trend showing improved deposition and protection installed by the nanoparticles is evident. qPCR analysis ( Figure 1b ) supported the northern findings, with higher levels of siRNA detected in organs isolated from animals treated with the chitosan/siRNA nanoparticles compared with those with naked siRNA.
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Protection and Systemic Translocation of siRNA Following Oral Administration of Chitosan/siRNA Nanoparticles.
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