Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease.

We detected the strongest, highly significant, positive pair-wise correlation for SNCA and UCHL1 mRNA levels in SN DA neurons from control as well as from PD brains ( Fig. 4 D).

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While in our data no correlation between miR-133b levels and SNCA expression was detectable ( Table 3 ), a negatively correlated association of miR-133b to TH expression was weakly significant for PD samples ( Table 3 ).

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