Decision-making and trait impulsivity in bipolar disorder are associated with reduced prefrontal regulation of striatal reward valuation.

Brain · 2014 · PMC4107743 · PMID 25009169

Europe PMC DOI

hedged sentences

0.0570

closest p · 1.1× alpha

0.0700

boldest claim

The sentences

marginally significantP = 0.057so close (0.05 < p ≤ 0.1)

The probability by risk-taking interaction was significant in dorsolateral PFC [ F (1,37) = 3.89, P = 0.05] and marginally significant in ventral striatum [ F (1,37) = 3.86, P = 0.057].

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approached significanceP = 0.058so close (0.05 < p ≤ 0.1)

In ventral striatum, a three-way group by probability by hemisphere interaction approached significance [ F (1,38) = 3.81, P = 0.058], which indicated that in left ventral striatum, the increase in activity for high-probability rewards (relative to low) was more pronounced in the bipolar disorder compared to healthy control group.

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failed to reach significanceP = 0.07so close (0.05 < p ≤ 0.1)

Although in the direction hypothesized, the probability by impulsivity interactions failed to reach significance in dorsolateral PFC ( P = 0.07) and ventral striatum ( P = 0.13).

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