The inherent mutational tolerance and antigenic evolvability of influenza hemagglutinin.

There is a highly significant correlation between the results of the two studies—but the inferred mutational effects are certainly not identical.

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These observations are supported by the statistical analyses in Table 4 : even after correcting for RSA, there is a significant trend for antigenic sites to have high mutational tolerance, and for conserved receptor-binding residues to have low mutational tolerance.

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