Barely Significant
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Sperm nuclear vacuoles in relation to acrosome reactions and sperm motility.

ScientificWorldJournal · 2014 · PMC4109670 · PMID 25097868

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highly significantno p-value reported
The authors simultaneously observed a highly significant decrease in the presence of vacuoles following acrosome reaction induction.

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showed a trendno p-value reported
However, a recent meta-analysis showed a trend towards an improvement in IMSI outcomes versus that obtained with ICSI [ 10 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.