Memory in multiple sclerosis is linked to glutamate concentration in grey matter regions.

J Neurol Neurosurg Psychiatry · 2014 · PMC4112488 · PMID 24431465

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

showed a trendp=0.054so close (0.05 < p ≤ 0.1)

Entering hippocampal MTR and hippocampal DIR lesions as predictors revealed that only hippocampal [Glu] showed a trend for predicting PAL trials at first attempt (coeff.=0.60, 95% CI −0.01 to 1.13, p=0.054, PCC=0.59).

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a trend towards significanceno p-value reported

When a significant association (or a trend towards significance) between [Glu] and cognitive test performance was found, a second linear regression model was run, entering the [Glu] of a specific VOI, the DIR GM lesions within the spectroscopic VOI and the MTR value of the VOI, as predictors, and the cognitive test performance as the dependent variable.

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