Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Medical and surgical management for pulmonary arterial hypertension.

Ann Thorac Med · 2014 · PMC4114282 · PMID 25077002

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did not reach statistical significanceno p-value reported

n of bosentan and prostacyclin were investigated in 22 modified NYHA class III and IV PAH randomized to receive either epoprostenol and placebo or epoprostenol and bosentan (BREATHE-2).[ 73 ] There was a trend towards a greater improvement in hemodynamic parameters in the combination group but that did not reach statistical significance.

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