A small molecule agonist THIQ as a novel pharmacoperone for intracellularly retained melanocortin-4 receptor mutants.

Int J Biol Sci · 2014 · PMC4115193 · PMID 25076858

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did not reach statistical significanceno p-value reported

In N1E-115 cells, 10 -5 M THIQ significantly increased the signaling of the six mutants that were also rescued in Neuro2a cells and one additional mutant (I69R) that had an increase that did not reach statistical significance in Neuro2a cells (Fig. 4 C).

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