However, the difference in firing rates between neurons expressing R353G mutant KCNQ2 and wild-type KCNQ2 at all current injection amplitudes did not reach statistical significance (p = 0.051–0.093 at 90–200 pA current injection) except at 170 pA (p = 0.04) ( Fig. 12B–D ).
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Polarized axonal surface expression of neuronal KCNQ potassium channels is regulated by calmodulin interaction with KCNQ2 subunit.
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