In the present study, the pre-treatment with ezetimibe showed an increasing trend in the cholesterol and LDL-C lowering effect of statin by 3.7% (p=0.10) and 5.0% (p=0.055), respectively, although these changes did not reach statistical significance.
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Influence of previous statin therapy on cholesterol-lowering effect of ezetimibe.
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borderline significancep=0.10
The differences in the effect of simvastatin on total cholesterol and LDL-C between the patients with and without ezetimibe showed borderline significance (p=0.10 and p=0.055, respectively).
The differences in the reductions of total cholesterol and LDL-C were of borderline significance (p=0.10 and p=0.055, respectively) ( Fig. 1 ).