IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms.

Reduced macrophages in AAA lesions from recipient mice receiving CD4 + T cells from Apoe −/− Fcer1a −/− mice yielded lower levels of MHC class-II—marker of inflammation (Zhang et al , 2012 )—in these AAA lesions, compared with those receiving CD4 + T cells from Apoe −/− mice, although such difference did not reach statistical significance (Fig 3 D, right panel).

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