Tsc2 Haploinsufficiency Has Limited Effects on Fetal Brain Cytokine Levels during Gestational Immune Activation.

Autism Res Treat · 2014 · PMC4119898 · PMID 25114803

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0.0900

closest p · 1.8× alpha

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a nonsignificant trendP = 0.09so close (0.05 < p ≤ 0.1)

An overall comparison of cytokine profiles (by three-way ANOVA with genotype and treatment as between-subjects factors and cytokine as within-subjects factor) showed a nonsignificant trend towards an effect of poly I:C ( P = 0.09), while there was no effect of genotype ( P = 0.34) and no genotype x treatment interaction ( P = 0.95).

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did not reach statistical significanceno p-value reported

At 6.5 h after poly I:C, cytokines appeared to be, overall, modestly elevated in poly I:C fetal brains relative to controls, although this finding did not reach statistical significance (Figures 3(a) and 3(b) ; two-way ANOVA, WT/saline versus poly I:C, treatment as between-subjects factor and cytokine as within-subjects factor: effect of treatment, P = 0.09).

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