Consistent with our discovery sample, multilevel principal component analysis showed a trend toward a separation between metabolic profiles pre- and postaspirin exposure in all subjects ( Supplementary Figure S2B ) and 15 individual metabolites changed significantly post- compared to preaspirin ( Table 2 , highlighted in bold), confirming the strong effect of aspirin on amine metabolites.
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Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability.
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