Partial deletion of eNOS gene causes hyperinsulinemic state, unbalance of cardiac insulin signaling pathways and coronary dysfunction independently of high fat diet.

PLoS One · 2014 · PMC4122412 · PMID 25093405

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a clear trendno p-value reported

As a result, the double ratio of pERK/pAkt showed a clear trend to increase in all eNOS-genetically modified groups as compared with WT (statistical significant in eNOS −/− and HFD-fed eNOS +/− ), pointing out a definite imbalance between the two molecular pathways downstream the insulin receptor.

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