showed a trendP = 0.045
A recent meta-analysis, taking into consideration twenty-eight trials enrolling 11,880 patients on DPP-4 inhibitors, showed a trend to reduced risk of fractures (odds ratio [MH-OR] 0.60, 95%CI 0.37–0.99, P = 0.045) in these patients compared to those on placebo [ 325 ].