Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis.

42 , 43 By contrast, sulfonamide 21l and carboxamide 24b did not target LPS- and BLP-mediated IL-12p40 responses, respectively. Sulfone 11a additionally targeted IL-6 production (see also Figure 3 B) in response to all three TLRs (although this did not reach statistical significance for TLR2 in all experiments), and this cytokine has also been shown to be pathogenic 44 and thus a therapeutic target (tocilizumab) in RA. 45 Although sulfone 12b could suppress CpG-mediated IL-6 responses, it was less effective at inhibiting such TLR2- or TLR4-coupled responses (decreases not reac

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