Protection versus pathology in aviremic and high viral load HIV-2 infection-the pivotal role of immune activation and T-cell kinetics.

Immune activation (HLA-DR/CD38 coexpression) differed between groups with a significant trend: controls <HIV-2-LV <HIV-1 <HIV-2-HV ( P < .01 for all cell types).

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When ranked in this order using a categorical variable ( 1 – 4 ), correlation analysis demonstrated a highly significant hierarchy for all four T-cell subpopulations (Figure 1 ).

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