Dissecting the regulatory microenvironment of a large animal model of non-Hodgkin lymphoma: evidence of a negative prognostic impact of FOXP3+ T cells in canine B cell lymphoma.

Rather than being lower in BCL cases, the median CD8 + :FOXP3 + ratio showed a trend towards being higher in this group of dogs when compared to RH (or MCT) cases (BCL: 2.09 [0–27.7], n = 22; RH: 1.63 [0–5.89], n = 13; MCT: 0.35 [0–1.07]; n = 4; p = 0.06), which became significant when thymic Tregs were specifically examined by means of co-expression of FOXP3 and Helios within the overall population (BCL: 15.6 [2.11–36.1], n = 11; RH: 4.26 [0–12.0], n = 13; p = 0.04) ( Figure 4D,E ).

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