Patients with poor response to antipsychotics have a more severe pattern of frontal atrophy: a voxel-based morphometry study of treatment resistance in schizophrenia.

More recently a study, directly assessing structural parameters in patients resistant to conventional antipsychotics using Region of Interest (ROI) analysis of segmented MRI [ 20 ], has shown that NonResp-SC patients have significantly lower gray matter (GM) volumes in the frontal and occipital regions and significantly more white matter (WM) in the frontal, parietal, and occipital regions as compared to the controls, while these alterations are less prominent in Resp-SC patients, although in that case the direct comparison between NonResp-SC and Resp-SC patients failed to reach statistical significance.

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