of borderline significancep = 0.053
Association of high LOX expression with liver-metastasis-free survival was of borderline significance (p = 0.053).
Association of high LOX expression with liver-metastasis-free survival was of borderline significance (p = 0.053).
However, there was a clear trend towards a decreased disease-free survival of A-carriers in unselected (p = 0.14) and, more pronounced, in ER negative patients (p = 0.1; Fig. 2B, E ).
In contrast, no increased risk was observed in a study of African American women (311 patients and 446 controls), although a possible trend towards an increased risk of ER negative breast cancer associated with the A-allele was suggested by these authors [4] .
Opposite to all other survival analyses, this effect was predominantely due to ER positive cases, with only a weak trend in ER negative patients.