A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome.

Similarly, the instantaneous frequency of spontaneous synaptic currents was significantly higher in the Nulls, resulting in a strong trend towards a higher number of events within a 2-minute period as well (representative trace in Fig. 1B ; sPSC frequency: Wt, 17.4±1.3 Hz, n =51; Null, 21.8±1.5 Hz, n =53; P <0.05; number of events: Wt, 599.8±64.5; Null, 772.6±89.5, P =0.07), with no significant effect of genotype on sPSC amplitudes.

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