A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.

It also increased the number of APP L/S mice that had neurites with ≥3 rd order branching (3 out of 5 mice), however this increase did not reach statistical significance ( Fig. 7F ).

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