Pyrroloquinoline Quinone Induces Cancer Cell Apoptosis via Mitochondrial-Dependent Pathway and Down-Regulating Cellular Bcl-2 Protein Expression.

Compared to the negative control, the fluorescent intensity of activated caspase-3 in A549 cells showed a trend of enhancing (15.50 ± 0.89 vs 15.50 ± 0.89 at 15 μM, p > 0.05; 18.43 ± 1.19 vs 15.50 ± 0.89 at 30 μM, p < 0.05; 22.90 ± 1.54 vs 15.50 ± 0.89 at 75 μM, p < 0.01; 42.83 ± 3.15 vs 15.50 ± 0.89 at 300 μM, p < 0.01) (Figures 6 A and 6 B).

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