Analysis of histological sections of muscle with the macrophage marker F4/80 showed a trend toward greater infiltration of macrophages in the Insl6-KO mice under CIM conditions, but this difference was not statistically significant (Additional file 2 : Figure S3).Using RNA isolated from lower limb muscles, qRT-PCR analyses were performed to measure the expression of inflammatory marker genes.
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The injury-induced myokine insulin-like 6 is protective in experimental autoimmune myositis.
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