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A preclinical physiological assay to test modulation of knee joint pain in the spinal cord: effects of oxycodone and naproxen.

PLoS One · 2014 · PMC4144976 · PMID 25157947

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Comparing the two groups at the end of each infusion using ratios of geometric means for naproxen to vehicle and 95% confidence intervals show that these effects were nearly statistically significant for the 60 minute rotation set where unbound plasma concentration of naproxen reached a mean peak of 697±45 nM ( Figure 4B ).

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