Sirukumab, a human anti-interleukin-6 monoclonal antibody: a randomised, 2-part (proof-of-concept and dose-finding), phase II study in patients with active rheumatoid arthritis despite methotrexate therapy.

In addition, 28.6% of sirukumab-treated patients had an ACR50 response at week 12 compared with 5.9% of patients who received placebo; however, while the numerical difference between the groups was approximately fivefold, it did not reach statistical significance (p=0.148) ( table 2 ).

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