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Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells.

Oncotarget · 2014 · PMC4148123 · PMID 24970803

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Aphidicolin suppressed to some extent niraparib's sensitization but this effect did not reach statistical significance suggesting that H 2 O 2 cytotoxicity is not completely mediated by conversion of SSBs to DSBs during DNA replication but may involve other aspects of SSB repair or toxic effects of H 2 O 2 that don't involve DNA damage.

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