In the present study, we show a significant correlation between EphA4 positive depositions and pTau-positive plaques and an almost significant correlation with pTau-positive tangles in AD.
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Altered distribution of the EphA4 kinase in hippocampal brain tissue of patients with Alzheimer's disease correlates with pathology.
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previously reported a correlation between the intracellular domain of EphA4 (EICD) and tau phosphorylation, although the correlation did not reach statistical significance.