On the other hand, telemetric BP showed a trend toward enhanced Ang II–induced BP elevation in ATRAP-KO mice, concomitant with a tendency of increase in day-by-day sodium balance in ATRAP-KO mice as compared with WT mice already during the early period of Ang II infusion ( Figures 3 and 4 ).
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Deletion of the angiotensin II type 1 receptor-associated protein enhances renal sodium reabsorption and exacerbates angiotensin II-mediated hypertension.
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