Geneva cocktail for cytochrome p450 and P-glycoprotein activity assessment using dried blood spots.

Clin Pharmacol Ther · 2014 · PMC4151019 · PMID 24722393

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

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The sentences

did not reach statistical significanceP = 0.06so close (0.05 < p ≤ 0.1)

A trend toward increased CYP2C19 metabolism (as determined by a lower omeprazole AUC and a higher 5′-hydroxyomeprazole/omeprazole (OH-opz/opz) AUC ratio) was noticed in five volunteers who were heterozygous carriers of CYP2C19*17 , but this did not reach statistical significance ( P = 0.06).

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