In this renal I/R experimental model, we found that 2ME2 significantly reduced the protein level of pNF- κ B and showed a trend toward decreasing TNF- α and IL-1 β mRNA production in the I/R+2ME2-treated groups, while it was increased in the I/R-only group, which indicates 2ME2's renoprotective effect against hypoxic stress.
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Anticancer drug 2-methoxyestradiol protects against renal ischemia/reperfusion injury by reducing inflammatory cytokines expression.
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