Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin.

In PINK1 −/− axons, however, there was a smaller Antimycin A–induced change in the fractions of mitochondria colocalizing with autophagosomes (from 3 to 8%), and that change did not reach statistical significance (P = 0.09; Fig. 9, C–E ).

also in 111,027 other papers