Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome.

PLoS One · 2014 · PMC4154723 · PMID 25188425

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did not reach statistical significanceno p-value reported

Normalizing the Dyrk1A copy number slightly reduced this hyperactivity in these animals, but this effect did not reach statistical significance.

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