Risk associations between HLA-DPB1 T-cell epitope matching and outcome of unrelated hematopoietic cell transplantation are independent of HLA-DPA1.

Also in line with previous observations, HLA-DPB1 allele matched transplants were associated with an increased risk of relapse compared to permissive or non-permissive transplants in univariate analysis ( Figure 2D ), but did not reach statistical significance when adjusted for significant co-variates ( Table 2 ).

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Interestingly, the reduced risk of leukemia relapse associated with non-permissive HLA-DPB1 TCE group mismatches was more marked in the present study (HR 0.55; p=0.002) than in the IHWG report (HR 0.80; p=0.02) 6 and highly significant, possibly reflecting greater disease type homogeneity for AML and MDS patients.

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