Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis.

Titration of Tregs suggested that the suppressive capacity of P3-enriched Tregs was lower than that of P2 at the lower Treg/Tcon ratio of 1:8; however, the differences between P2 and P3 did not reach statistical significance ( p = 0.0787 [paired t test] at a 1:8 ratio, Fig. 5G ).

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