Potentially functional polymorphisms in the ERCC2 gene and risk of esophageal squamous cell carcinoma in Chinese populations.

For rs238406, however, we found a statistically significant trend for the allele G → T effect on ERCC2 mRNA expression in Europeans ( P trend = 0.011) but a borderline significance in CHB ( P trend = 0.098).

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In the present study, we also found a significant trend for the rs13181 allele T → G effect on ERCC2 transcript expression levels in different ethnic populations, indicating that the ERCC2 rs13181 SNP may be a underlying genetic determinant of esophageal cancer risk.

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