A systems biology approach reveals a link between systemic cytokines and skeletal muscle energy metabolism in a rodent smoking model and human COPD.

Genome Med · 2014 · PMC4165371 · PMID 25228925

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a clear trendno p-value reported

Notably, there is a clear trend toward significant induction of TNF- α plasma levels of CS-exposed guinea pigs, suggestive of a similar systemic inflammatory process in this model organism [ 16 ].

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