Barely Significant
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Humanized TLR7/8 expression drives proliferative multisystemic histiocytosis in C57BL/6 mice.

PLoS One · 2014 · PMC4168129 · PMID 25229618

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showed a trendno p-value reported
Even though IL-12p40 and IL-10 were significantly increased in hu TLR7/8 BAC+ mice compared to Tlr7/8 DKO mice, the control uninjected hu TLR7/8 BAC+ mice also showed a trend towards higher levels than the DKO mice suggesting that human TLR7 or TLR8 might be constitutively activated in the BAC+ mice.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.