Even though IL-12p40 and IL-10 were significantly increased in hu TLR7/8 BAC+ mice compared to Tlr7/8 DKO mice, the control uninjected hu TLR7/8 BAC+ mice also showed a trend towards higher levels than the DKO mice suggesting that human TLR7 or TLR8 might be constitutively activated in the BAC+ mice.
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Humanized TLR7/8 expression drives proliferative multisystemic histiocytosis in C57BL/6 mice.
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