Ctla-4 modulates the differentiation of inducible Foxp3+ Treg cells but IL-10 mediates their function in experimental autoimmune encephalomyelitis.

PLoS One · 2014 · PMC4169598 · PMID 25238105

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did not reach statistical significanceno p-value reported

Still, the adoptive transfer of splenic CD4 + CD25 + Foxp3 + Tg4 IL-10 +/+ Treg cells appeared to limit disease progression in Tg4 IL-10 −/− mice, although this did not reach statistical significance in our experimental set-up ( Figure 2A ).

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