The response of head and neck squamous cell carcinoma to cetuximab treatment depends on Aurora kinase A polymorphism.

The knockdown of each kinase caused a drastic and highly significant decrease in clonogenic survival (Fig. 3 ), an effect that was independent of AurkA polymorphism (Cal27 - siAurkA p = 0.0048, siAurkB p = 0.0084; HN - siAurkA p = 0.0004, siAurkB p = 0.0076).

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The Cal27 cells showed a trend of a higher amount of apoptotic cells upon treatments, though cetuximab treatment alone induced only a small but significant amount of apoptosis in these cells (p = 0.0267).

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