Mechanistic target of rapamycin (mTOR): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer cells.

Front Physiol · 2014 · PMC4171984 · PMID 25295009

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showed a trendno p-value reported

However, a meta-analysis of nine observational studies showed a trend but failed to show a significant association between metformin and PDAC risk (Singh et al., 2013 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.