The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.

8 C ) confirmed that the Hck −/− Fgr −/− Lyn −/− mutation strongly inhibited the immune complex–induced release of KC (P = 0.0013; n = 5), MCP-1 (P = 0.010; n = 4), and TNF (P = 4.0 × 10 −4 ; n = 4) from macrophages, caused a partial but statistically significant inhibition of MIP-2 release (P = 0.027; n = 4), and led to an apparent reduction of MIP-1α release which, however, did not reach statistical significance (P = 0.29; n = 4).

also in 111,027 other papers