Barely Significant
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ABCC5 transporter is a novel type 2 diabetes susceptibility gene in European and African American populations.

Ann Hum Genet · 2014 · PMC4173130 · PMID 25117150

Europe PMCDOI
1
hedged sentence
0.0010
closest p · 0.0× alpha
0.0010
boldest claim

The sentences

nominally significantP = 1E−03actually significant
In relation to why previous GWA studies have not previously identified ABCC5 as a T2D susceptibility gene, it is worth noting that while individual nominally significant SNP p-values nearest to the estimated ABCC5 variant location at 185,136 kb for the WTCCC (e.g. rs3749441, P = 1E−03), NIDDK (e.g. rs1016752, P = 0.04) and TwinsUK samples (e.g. rs8180093, P = 0.002) do not pass genome-wide significance ( α = 1E−05), when all the SNPs in the region are considered collectively as part of a multilocus model, they do provide strong evidence of association with T2D and insulin resistance (meta-analysis P = 3E−07).

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