Comparison of MPs in FH patients with those in healthy volunteers showed a trend (nonsignificant) toward an increase in total concentration; however, the size distribution showed individuals with FH had increased concentrations of MPs between 50 and 100 nm ( P < 0.05, supplementary Fig.
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Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia.
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Total MP concentration also appears elevated in individuals with FH, though this did not quite reach significance.