Interestingly, when we plotted the fold change difference between Δ greA Spn and wild type as a function of gene expression strength (similar to a MA-plot ( 40 )), a clear trend is visible in that highly expressed genes were affected more by the absence of GreA Spn than lowly expressed genes (Figure 3A , R = 0.36).
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Control of transcription elongation by GreA determines rate of gene expression in Streptococcus pneumoniae.
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