Skeletal muscle myofilament adaptations to aging, disease, and disuse and their effects on whole muscle performance in older adult humans.

These molecular and cellular level differences were reflected in a similar pattern of differences in isokinetic torque at the whole muscle (i.e., lower torque in female knee osteoarthritis patients), albeit these tissue-level differences did not reach statistical significance, possibly due to our small sample size and/or sex-specific effects of pain-induced neural inhibition associated with knee osteoarthritis.

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