The impact of single and pairwise Toll-like receptor activation on neuroinflammation and neurodegeneration.

J Neuroinflammation · 2014 · PMC4182775 · PMID 25239168

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a slight trendno p-value reported

Co-cultures of microglia and neurons incubated with the DAMP HSP60 plus the PAMP LPS, both activating TLR4, showed a slight trend of increased neuronal decay compared to the one induced by the respective single stimulus.

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did not reach statistical significanceno p-value reported

Furthermore, a trend towards increased secretion of CCL5 and GM-CSF after incubation with Pam3CysSK4 plus HSP60 compared to the respective single application was observed, although these results did not reach statistical significance (Figure 3 B).

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