Hemizygous Le-Cre transgenic mice have severe eye abnormalities on some genetic backgrounds in the absence of LoxP sites.

Although the frequency of Le-Cre Tg/− ; Pax6 +/+ eye abnormalities was higher at stage 3 than stage 1 this difference did not reach statistical significance either for all abnormalities (4/6 vs. 2/6; P = 0.5671) or severe abnormalities (3/6 vs. 0/6; P = 0.1818).

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In each case there is a trend for fewer wounds to close in CBA/Ca- Pax6 +/Sey-Neu positive controls and Le-Cre Tg/− ; Pax6 fl/+ experimental mice than in Le-Cre −/− ; Pax6 +/+ , Le-Cre −/− ; Pax6 fl/+ or Le-Cre Tg/− ; Pax6 +/+ control groups but most differences failed to reach significance by Fisher's Exact tests unless results for left and right eyes were pooled.

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