Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid.

2 A–D; left panels) but these increments did not reach statistical significance.

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There were marginally significant and significant differences in the averaged and maximal radial spread of fluorescent Aβ 1-40 , respectively, between vehicle- and cilostazol-treated Tg-SwDI mice at 15 months of age (13.5-month cilostazol treatment vs. vehicle; 2783 ± 234 μm vs. 2395 ± 186 μm for average spread, P = 0.057; 3678 ± 238 μm vs. 2820 ± 386 μm for maximum spread, P = 0.028) (Fig. 3 D and E).

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