Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children.

SNPs that showed a trend for association (7 SNPs with p ≤ 0.01) with either maximum BMI in adulthood or maximum BMI z score in childhood, or were predicted to be damaging using the Ingenuity Variant Analysis (rs11872992) were further genotyped in all remaining subjects ( n = 3,852, mixed-heritage American Indians, Supplementary Table 1).

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